{"id":4585,"date":"2025-10-13T09:03:06","date_gmt":"2025-10-13T09:03:06","guid":{"rendered":"https:\/\/www.biostherapy.it\/bios-therapy-patents\/"},"modified":"2026-08-07T12:48:56","modified_gmt":"2026-08-07T12:48:56","slug":"bios-therapy-patents","status":"publish","type":"page","link":"https:\/\/biostherapy.it\/en\/bios-therapy-patents\/","title":{"rendered":"Bios-Therapy Patents"},"content":{"rendered":"

[vc_row][vc_column offset=”vc_col-xs-12″][vc_column_text css=””]Epigen AU\/11: A Natural Matrix For Restoring Homeostasis In Cancer Cell-infiltrated Tissue<\/strong><\/p>\n

US 12,571,794 B2<\/a><\/p>\n

Year:<\/strong> 2026<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a 100% natural product
\nconsisting of natural matrices showing emerging properties,
\nwhich allows to re-establish a correct metabolism in tissues
\ninfiltrated by cancer cells, adjuvating cancer treatment and
\ntissue homeostasis. The product of the invention, as dem-
\nonstrated by the inventors, is itself a natural matrix, repre-
\nsenting native natural intelligence, said natural intelligence
\nbeing the only capable to allow a physiological endogenous
\ninterconnection with other entities which are self-assembled
\nin nature, such as the human species. By modulating tumor
\nmicroenvironment and thus selectively inducing cancer cells
\nmortality, the product achieves reconstitution of conditions
\nfavourable to tissue homeostasis in tissues infiltrated by
\ncancer cells. Factually, the invention allows for a shift of
\nparadigm based on the passage from a deterministic valida-
\ntion of properties to a probabilistic one based on functional
\nredundancy logics, that will grant an industrially viable
\nsource of innovation for manufacturers in the field of 100%
\nnatural therapeutic or beneficial products.<\/p>\n

\n

A Natural Matrix Mixture for the Treatment of Bone Fragility<\/strong><\/p>\n

European Patent Office EP 4 687 934 B1<\/a><\/p>\n

Year:<\/strong> 2026<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a 100% natural product
\nconsisting of natural matrices showing emerging properties,
\nwhich allows to re-establish a correct metabolism in tissues
\ninfiltrated by cancer cells, adjuvating cancer treatment and
\ntissue homeostasis. The product of the invention, as dem-
\nonstrated by the inventors, is itself a natural matrix, repre-
\nsenting native natural intelligence, said natural intelligence
\nbeing the only capable to allow a physiological endogenous
\ninterconnection with other entities which are self-assembled
\nin nature, such as the human species. By modulating tumor
\nmicroenvironment and thus selectively inducing cancer cells
\nmortality, the product achieves reconstitution of conditions
\nfavourable to tissue homeostasis in tissues infiltrated by
\ncancer cells. Factually, the invention allows for a shift of
\nparadigm based on the passage from a deterministic valida-
\ntion of properties to a probabilistic one based on functional
\nredundancy logics, that will grant an industrially viable
\nsource of innovation for manufacturers in the field of 100%
\nnatural therapeutic or beneficial products.<\/p>\n

\n

Methods for Determining When a Natural Therapeutic or Beneficial Product Exerts Its Therapeutic or Beneficial Effect Through a Physiological Mode of Action<\/strong><\/p>\n

Australia 2024204105<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to new methods enabling the evolution of the medical arts passing from the use of artificial substances that are chemically or biologically defined to self-assembling natural entities, obtained from natural raw materials with industrial processes that preserve the endogenous properties thereof, thereby preserving their capability to interact with the networks of the living kingdom (including humans); wherein said natural entities cannot be defined with the classical quali-quantitative composition schemes. The invention therefore provides new methods for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect through a physiological mode of action. This method provides a necessary tool for the skilled person to assess the mechanism of action of a therapeutic or beneficial product which, with the new developments in the regulatory framework for medical devices and food supplements has become a relevant feature to assess and for which no methods are available in the art.<\/p>\n

\n

Methods For Defining The Acceptability Values Of Spectroscopy For Batch To Batch Validation Of Natural Matrices-Based Therapeutic Or Beneficial Product<\/strong><\/p>\n

Canada 3225879<\/a><\/p>\n

Year:<\/strong> 2026<\/p>\n

Inventors:<\/strong> Mercati, Valentino, Jacopo Lucci<\/p>\n

Abstract:<\/strong>
\nThe present invention relates to new batch control methods for products comprising or
\nconsisting of a natural matrix or mixtures of vegetal matrices, said products being characterised
\nby the fact that the matrix or matrices themselves show distinctive emerging properties different
\nfrom those represented by the sum of the properties of their individual components.<\/p>\n

\n

Validation of Natural Matrices for Therapeutic Use<\/strong><\/p>\n

USA 12546707 B2<\/a><\/p>\n

Year:<\/strong> 2026<\/p>\n

Inventors:<\/strong> Mercati, Valentino, Jacopo Lucci<\/p>\n

Abstract:<\/strong>
\nThe present invention relates to a new method for assessing acceptability ranges or cut-offs for the compliance validation of batches of products comprising or consisting of one or more natural matrix, wherein said products have an ascertained therapeutic or beneficial effect. The invention also relates to a new process for the compliance validation of one or more batches of said products.<\/p>\n

\n

Epigenau\/11: A Natural Matrix with Therapeutic Activity through a Physiological Network Mechanism of Action (Not Pharmacological) for Restoring Homeostasis in Tissues Infiltrated by Cancer Cells<\/strong><\/p>\n

Australia 2025200734<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucc, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct metabolism in tissues infiltrated by cancer cells, adjuvating cancer treatment and tissue homeostasis. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By modulating tumor microenvironment and thus selectively inducing cancer cells mortality, the product achieves reconstitution of conditions favourable to tissue homeostasis in tissues infiltrated by cancer cells. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.<\/p>\n

\n

Method for Determining When a Natural Therapeutic or Beneficial Product Exerts Its Therapeutic or Beneficial Effect Via a Physiological Mechanism<\/strong><\/p>\n

Japan 7654293<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to new methods enabling the evolution of the medical arts passing from the use of artificial substances that are chemically or biologically defined to self-assembling natural entities, obtained from natural raw materials with industrial processes that preserve the endogenous properties thereof, thereby preserving their capability to interact with the networks of the living kingdom (including humans); wherein said natural entities cannot be defined with the classical quali-quantitative composition schemes. The invention therefore provides new methods for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect through a physiological mode of action. This method provides a necessary tool for the skilled person to assess the mechanism of action of a therapeutic or beneficial product which, with the new developments in the regulatory framework for medical devices and food supplements has become a relevant feature to assess and for which no methods are available in the art.<\/p>\n

\n

A New Qualiquantitative Benefit\/Risk Assessment Method Suitable for the Physiological Activity of Natural Matrices-Based Therapeutic or Beneficial Products with Respect to That of Other Products with Pharmacological or Nutraceutical Activity Based on Synthetic Molecules<\/strong><\/p>\n

Australia 2025202615<\/a><\/p>\n

Year<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino, Jacopo Lucci<\/p>\n

Abstract<\/strong>:<\/p>\n

A new qualiquantitative benefit\/risk assessment method suitable for the physiological activity of natural matrices-based therapeutic or beneficial products with respect to that of other products with pharmacological or nutraceutical activity based on synthetic molecules. The present invention provides a new predictive in vitro or ex vivo method for defining the benefit\/risk score of a therapeutic or beneficial product, a method based on data obtained from in vivo experiments for defining the benefit\/risk score of a therapeutic or beneficial product as well as method for selecting therapeutic or beneficial products for further development. A new qualiquantitative benefit\/risk assessment method suitable for the physiological activity of natural matrices-based therapeutic or beneficial products with respect to that of other products with pharmacological or nutraceutical activity based on synthetic molecules.<\/p>\n

\n

Method for Defining Spectral Acceptance Values for Validation of One or More Test Batches of a Product for Pathological Conditions Using Spectroscopic Analysis<\/strong><\/p>\n

Japan 7616724<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a new method for defining acceptability values of the spectroscopy or spectrophotometry spectra for the compliance validation of batches by means of spectroscopy or spectrophotometry analysis of therapeutic or beneficial products, the products comprising or consisting of one or more natural matrices. The invention also relates to a new process for the compliance validation of one or more batches of said products.<\/p>\n

\n

A Natural Matrix Mixture for the Treatment of Bone Fragility<\/strong><\/p>\n

Australia 2024287156<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.<\/p>\n

\n

A Natural Matrix Mixture for the Treatment of Bone Fragility<\/strong><\/p>\n

Japan 7719544<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.<\/p>\n

\n

Validation of Natural Matrices for Therapeutic Use on Humans, Animals and Plants on Bio-Physical Bases as an Alternative to Validation through Chemically Definable Substances Derived from Said Matrices by Isolation and\/or Synthesis Processes and Also as an Alternative to Products Comprising Natural Matrices Validated on the Basis of Their Traditional Use<\/strong><\/p>\n

Australia 2024203121<\/a><\/p>\n

Year:<\/strong> 2025<\/p>\n

Inventors:<\/strong> Mercati, Valentino and Lucci, Jacopo<\/p>\n

Abstract:<\/strong> The present invention relates to a new method for defining acceptability values of the spectroscopy or spectrophotometry spectra for the compliance validation of batches by means of spectroscopy or spectrophotometry analysis of therapeutic or beneficial products, the products comprising or consisting of one or more natural matrices. The invention also relates to a new process for the compliance validation of one or more batches of said products.<\/p>\n

\n

New Composition for the Treatment of Articular Disorders<\/strong><\/p>\n

USA 11612628<\/a><\/p>\n

Year:<\/strong> 2023<\/p>\n

Inventors:<\/strong> Mercati, Valentino, Ghelardini, Carla and Di Cesare Mannelli, Lorenzo<\/p>\n

Abstract:<\/strong> The present invention relates to new compositions suitable for use in the treatment of articular disorders (or conditions), processes for preparing said compositions and use of said compositions in therapeutic treatments of articular disorders.<\/p>\n

\n

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[vc_row][vc_column offset=”vc_col-xs-12″][vc_column_text css=””]Epigen AU\/11: A Natural Matrix For Restoring Homeostasis In Cancer Cell-infiltrated Tissue US 12,571,794 B2 Year: 2026 Inventors: Mercati, Valentino and Lucci, Jacopo Abstract: The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct metabolism in tissues infiltrated by cancer cells, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"one-page-template.php","meta":{"footnotes":""},"class_list":["post-4585","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/pages\/4585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/comments?post=4585"}],"version-history":[{"count":14,"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/pages\/4585\/revisions"}],"predecessor-version":[{"id":5077,"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/pages\/4585\/revisions\/5077"}],"wp:attachment":[{"href":"https:\/\/biostherapy.it\/en\/wp-json\/wp\/v2\/media?parent=4585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}